Introduction to Structural Biology

The textbook for the class was T.E. Creighton's Proteins: Structures and Molecular Properties, 2nd Edition. The reccomended thext was C. Branden and J. Tooze's Introduction to Protein Structure.

NOTE: Most of these links don't go anywhere; these notes had a lot of diagrams and graphs which didn't translate well into html. This page is only intended to provide a list of topics covered in the class.

Table of Contents

Introduction

Amino Acid Chemistry

X-ray crystallography

NMR

Conformational Transformations

Thermodynamics

Introduction: Protein Stability and Denaturation

Thermal Denaturation

Forces that Stabilize the Protein or the Unfolded State

Water and Hydrophobocity

Polar and Electrostatic Interactions

Protein Dynamics and Folding

Protein Design and Structure Prediction

Enzymes

Specificity and Catalysis

Binding, Kinetics, and Inhibitors

Catalytic Antibodies

Serine Proteases and Lysozyme: Evidence for Mechanisms

Nucleic Acid Chemistry and Conformation

DNA Structure

Structure of Base Pairs and Base Steps

Local Helix Geometry

Tertiary Structures

RNA Structure and Enzymes

Binding Proteins

Back to Sev's Education Page